The Four Seas

 From the South:
Take I-55 North to Truman Parkway  
Turn left onto Lafayette Ave.  
Turn left onto Mississippi Ave. 
Turn right onto Geyer Ave., go 1 block   
The Four Seas will be on the left. parking on right  
    
From the West:   
Take I-44, I-40, or I-64 East to Jefferson Ave. Exit
Turn right onto Jefferson Ave.     
Turn left onto Russell
Turn left onto McNair 
The Four Seas will be on the right, parking ahead
 

From Illinois:
Take I-55 South (55/44 ramp) to Gravois Exit
Turn right onto Russell
Go 2 blocks and make a right at McNair
The Four Seas will be on the right, parking ahead